CHEMOTHERAPY-ELICITED EXOSOMAL MIR-378A-3P AND MIR-378D PROMOTE BREAST CANCER STEMNESS AND CHEMORESISTANCE VIA THE ACTIVATION OF EZH2/STAT3 SIGNALING

Abstract Background Not all breast cancer (BC) patients who receive neoadjuvant chemotherapy achieve a pathologic complete response (pCR), but the reasons for this are unknown.Previous studies have shown that exosomes produced in the tumor microenvironment in response to chemotherapy promote a chemotherapy-resistant phenotype in tumors.However, the

Understanding of the role of body mass in structural-functional relationships is pressing, particularly because species losses often occur non-randomly with respect to body size.Our study examined the effects of dung beetle body mass on dung removal at two levels.First, we used the lab experiment to evaluate the efficiency of eight dung beetle spec

The purpose of the study is to evaluate the policy commitment of North Sumatera provincial government in mitigating climate change (case study of mangrove protection).The Regional Action Plan for Greenhouse Gas (RAD-GRK) has been adopted in 2012 by the Province of North Sumatra.The action plan identifies action needed to rehabilitate mangroveswithi